Jamie (Michael Cera) an American living in Chile, and his Chilean friend Champa (Juan Andrés Silva) have made plans to go on a road trip into the desert and ingest the psychedelic San Pedro cactus with Champa’s younger brothers (Agustín and José Miguel Silva). While at a house party the night before the trip, Jamie smokes weed, snorts coke and accidentally invites the hippie girl he just met to go on the trip with him.  By morning, Jamie has forgotten about the previous night and the boys hit the road. But the girl (Gaby Hoffman), and American who calls herself Crystal Fairy, hasn’t forgotten—she’s on a bus to the desert and calls Jamie, asking to be picked up.